PRECISE (Predictive Relationships Explaining Cancer Genetic Interactions and Synthetic Essentiality) is a pan-European initiative that aims to move cancer research beyond cataloguing cancer vulnerabilities towards predicting them before they are experimentally tested. Human Technopole (HT) is among the founding partners of the consortium, with Francesco Iorio leading its scientific activities across the institute alongside other HT research groups. The consortium and its scientific vision are presented in a Nature Genetics commentary.