The Core Technologies for Life Sciences (CTLS) Congress 2027 is the leading European event dedicated to research core facilities and shared scientific infrastructures. Held in Milan from 22 to 25 June 2027, the congress will bring together researchers, core facility professionals, research infrastructure managers, technology developers, industry representatives and policy makers to discuss the future of technology-enabled life science research. The programme will explore emerging technologies, artificial intelligence, FAIR data, innovation, industry collaborations and the evolving role of core facilities, while providing extensive networking opportunities across the international community.